Microdosing — the regular administration of minimal amounts of a lysergamide — is one of the most exciting research trends of recent years, and getting started is easier than you think. No altered perception, no hours-long sessions, no sitter needed. Instead: subtle changes in creativity, focus, and well-being that unfold over weeks.

I am Milo, and I have been engaged with microdosing for over three years. At first, I was sceptical — genuinely. "An amount you cannot even feel is supposed to do something?" Sounds like homoeopathy for nerds. But then I tried it, documented it, evaluated it — and fundamentally changed my mind. In this article, I share my knowledge with you: what microdosing is, how to start, which derivative works best, and what you can realistically expect.

Microdosing means taking a sub-perceptual dose of a lysergamide — an amount so small that you notice no discernible psychoactive effects. No altered vision, no altered thinking, no "research session." If you notice obvious effects, your dose was too high.

The Numbers

The typical microdose for LSD derivatives ranges from 5 to 20 micrograms. For comparison: a full research dose is 100-200 micrograms. We are talking about 5-15% of a standard dose. In a meta-analysis by Polito and Stevenson (2019), which evaluated 18 studies with a combined total of over 4,000 participants, the average microdose was 13 micrograms.

Before we get into the practical aspects, let me be honest: the scientific evidence on microdosing is promising but not conclusive. There are both encouraging and sobering study results. As a responsible researcher, you should be aware of both sides.

What the Studies Show

Positive findings:

• A study by Prochazkova et al. (2018) at the University of Leiden found that microdosing significantly improved convergent and divergent creativity — immediately after administration.
• Anderson et al. (2019) surveyed over 900 microdosing practitioners and found improvements in mood, focus, and creativity as the most commonly reported benefits (79%, 62%, and 53% of respondents).
• Hutten et al. (2020) demonstrated in a controlled study that microdosing with LSD could influence emotional reactivity and cognitive flexibility.

Sobering findings:

• Szigeti et al. (2021) conducted the largest placebo-controlled microdosing study to date (191 participants) and found no significant differences between the microdosing and placebo groups in terms of well-being and cognition.
• The question of whether microdosing effects go beyond the placebo effect has not been conclusively answered scientifically.

My Honest Assessment

Is microdosing a miracle solution? No. Is it complete nonsense? Also no. The truth lies — as so often — somewhere in between. What I take away from three years of experience and hundreds of community conversations: microdosing appears to produce noticeable effects in some people, but not in others. Individual variation is enormous.

And that is precisely why personal research is so valuable. You can only find out whether it works for you by trying it systematically and documenting it. Not for one week — for at least 6-8 weeks.

Short answer: 1BP-LSD pellets. For one simple reason: precision.

Why Pellets Are a Game-Changer

Imagine you want to take exactly 10 micrograms every third day. With a blotter (100 mcg) you would need to:

1. Cut the blotter into 10 equal pieces (good luck — the substance distribution on blotters is rarely homogeneous)
2. Or dose volumetrically: dissolve the blotter in distilled water, calculate the concentration, measure with a pipette

Both methods work, but both are error-prone and laborious. With 1BP-LSD pellets (10 mcg) you simply take one tablet — done. The dosing is factory-precise, there is no preparation, no calculation, no source of error.

For those who prefer the DIY approach: for the volumetric method I recommend the drops — but more on that later.

Microdosing is not "take a little bit every day" — it follows a structured protocol with fixed dosing and rest days. The breaks are critical, because lysergamides build tolerance rapidly. Without breaks, the effects would diminish entirely within a few days.

The Three Most Common Protocols

My Recommendation for Beginners

Start with the Fadiman Protocol. It is the best documented, has the longest track record, and the built-in two rest days give you enough distance to clearly distinguish effects from placebo. In a survey of 1,500 microdosing practitioners (Fadiman & Korb, 2019), 75% of participants using the Fadiman Protocol reported an overall positive experience.

Let me manage expectations, because this is where most mistakes are made online.

What Microdosing Is NOT

• Not a coffee replacement (it does not make you "more awake")
• Not an antidepressant (it does not replace therapy or medication)
• Not a nootropic in the classical sense (no immediately noticeable effects)
• Not a miracle productivity booster

What Microdosing COULD Be

Based on community reports and existing studies, researchers most commonly report:

• Slightly improved mood (not euphoria — more like: less reactive to stress, a bit more equanimity)
• Subtly increased creativity (more ideas, more unusual associations)
• Better focus (ability to stay on task longer)
• Increased mindfulness (more present in the moment, noticing details)
• Improved social interaction (more open, more empathetic)

Note: all of these effects are subtle. If you expect a dramatic difference, you will be disappointed. If you are open to small, cumulative changes over weeks — then microdosing could be fascinating for you.

In Anderson's study (2019), 26% of respondents also stated that microdosing had helped them reduce unhealthy habits — from excessive coffee intake to screen time. Whether this is a direct effect or a result of heightened mindfulness remains open.

1. Inform yourself (you are here — check)
2. Get 1BP-LSD pellets (10 mcg — precise and uncomplicated)
3. Document your baseline (3-5 days, daily ratings)
4. Start with the Fadiman Protocol (1 day on, 2 days off)
5. Keep a research journal (every day, not just on microdosing days)
6. Evaluate after 4-6 weeks (honestly, data-based, without wishful thinking)
7. Take a break (at least 2 weeks)
8. Share your experiences (the community benefits from every data point)

Microdosing is not a sprint — it is a marathon. The most interesting insights come not after the first day, but after the first complete cycle. Be patient, be systematic, and be honest with yourself.

And who knows — in a few weeks you might be sharing your own experience here in the community. We researchers look forward to every new data point.