100mcg LSD Blotters

100mcg LSD blotters — the standard research dose

You are looking for the 100mcg LSD blotter as a standard-size unit for your research series? Reasonable. The 100 µg unit has been the reference dose in published lysergamide literature for decades — and therefore the clean entry point for any effect-profile study. Our batches are HPLC-tested, you pull the certificate of analysis via the batch number. Purity 99 %+, EU shipping in 48 hours, free from 50 €.

This page is a sub-category of All Blotters. Format properties of the blotter paper (absorbency, storage, travel suitability) are described in detail there — here we focus on the 100 µg dose and its role in research protocols.

Why 100 µg as the standard size?

The 100 microgram unit is by far the most frequently cited standard dose in peer-reviewed lysergamide research literature. It sits clearly above the sub-perceptual microdose range (10 µg) and within the classic standard profile — the dose range in which onset, Tmax and duration can be measured reproducibly. For binding studies on the 5-HT2A receptor, for PK comparison series and for standard effect-profile assessment, 100 µg is the consensus entry.

Available compounds

Our 100 µg blotters come with two compounds: the compound 1Bp-LSD and the compound 1Fe-LSD. Both are 1-acylated lysergamides, both are hydrolytically converted to LSD-25 via their respective acyl group. Which compound fits your research design depends on what you want to investigate — for comparative PK studies, both are used in parallel.

What is behind the 100 µg variant?

A 100 µg blotter is a perforated paper square — typically 7.5 × 7.5 mm to 10 × 10 mm — impregnated with exactly 100 micrograms of a 1-acylated lysergamide. The compound quantity results from a controlled volumetric dosing of the carrier solution onto each square. With clean production, variation per square stays below ±5 %, achieved through standardised sheet manufacturing and sample checks.

100 µg as a research-dose reference

In older and newer research literature alike, 100 µg is the value against which other doses are compared. Anyone recording a dose-response curve typically sets a point at 100 µg, because onset times, plasma Cmax values and duration can be measured most robustly there. The standard duration of a lysergamide in this dose range falls between 8 and 12 hours, with oral onset at 30–60 minutes.

Suitability for entry into effect-profile studies

Anyone characterising a new 1-acylated derivative in their own research group almost always begins at the 100 µg dose. The reason: at sub-perceptual doses most endpoints sit below the detection limit, while at higher doses comparability with published studies becomes harder. 100 µg delivers enough signal to capture receptor binding affinity, half-life and onset cleanly.

Profile comparison to the higher dose

Anyone who has established the standard profile at 100 µg and wants to move into higher dose ranges typically reaches for the 175 mcg variant. The 175 µg dose is not simply "more of the same" — at higher doses, effect-profile phases, Tmax and duration shift measurably upwards. For reproducible dose series, it makes sense to source both doses from the same batch where available.

Compound choice: 1Bp-LSD vs. 1Fe-LSD

Both variants hydrolyse to LSD-25 in vivo, but via different acyl groups. 1Bp-LSD carries a butanoyl/bromobenzoyl group on the indole nitrogen, 1Fe-LSD carries a furoyl group. The acyl chain structure influences ester stability and hydrolysis rate — reflected in different onset times and bioavailabilities. For comparative PK studies, both 100 µg blotters are used in parallel.

Quality assurance and laboratory analysis

With 100 µg blotters, dose precision is the most important analytical metric. Each batch is analysed by HPLC — and in two stages: starting solution before impregnation and finished blotters after drying. Anything below 99 % purity does not go on sale.

HPLC quantification per sheet

After impregnation, individual 100 µg blotters are extracted from the sheet on a sample basis and the compound content is verified. Tolerance per square: below ±5 %. For particularly demanding research applications, variation can be further reduced through sheet averaging — see the certificate of analysis for details.

Identity confirmation via GC-MS

On selected batches, GC-MS supplements HPLC quantification. That matters because 1-acylated lysergamides can have chromatographically similar retention times among each other. Mass spectrometry delivers the unambiguous identity proof — 1Bp-LSD and 1Fe-LSD carry distinct mass signatures for their respective acyl groups.

Batch tracking and storage

Every sheet shipment has a unique batch number. Through this you retrieve the HPLC certificate online. With correct storage (dry, dark, 2–8 °C, light-tight packaging) 100 µg blotters stay stable for at least 12 months. Main enemies are light, oxygen and moisture — all three minimised by the original packaging.

100mcg vs. 175mcg vs. 200mcg — doses compared

Applications of the 100 µg variant in research

The 100 µg dose is the standard format for effect-profile studies on 1-acylated lysergamides. In practice this covers several research fields in which 100 µg is the reference against which other doses are compared.

Standard effect-profile studies

Anyone characterising onset, Tmax, duration and plateau phase of a lysergamide sets 100 µg as the reference point. Standard oral onset sits at 30–60 minutes, Tmax at 90–120 minutes, total duration at 8–12 hours. These values are established in literature for classic LSD-25 — and thereby form the comparison window for the 1-acylated prodrug derivatives.

Receptor binding studies

For binding studies on the 5-HT2A receptor (in vitro or ex vivo) 100 µg blotters provide a cleanly defined standard dose. EC50 values for LSD-25 sit in the low nanomolar range; comparative binding data for the 1-acylated derivatives require reproducible precursors — given with HPLC-tested blotters at 99 %+ purity.

Comparison studies between 1Bp-LSD and 1Fe-LSD

Running both compounds in parallel is one of the most common applications for 100 µg blotters. Onset, half-life, bioavailability — these parameters differ measurably between the acyl groups. The 100 µg dose delivers enough signal for clean PK datasets without entering the non-linear high-dose range.

Method development in forensic labs

Forensic and toxicology labs need reference material with documented compound quantity. For method validation of HPLC, GC-MS and LC-MS/MS protocols, 100 µg blotters are a practical reference format — compact, with unambiguous batch number and reproducible dose per unit.

Ordering 100 µg blotters — simple and discreet

You want to order 100 µg blotters? Three steps: choose compound (1Bp-LSD or 1Fe-LSD), pick quantity, complete the order. Shipped in discreet neutral packaging.

Fast ordering process

Orders placed by 14:00 ship the same working day. For study series we recommend ordering the full quantity in one go — that way all blotters come from the same batch, with identical compound quantity per unit.

Flexible payment options

Accepted: bank transfer (SEPA), cryptocurrencies and other secure payment routes. Encrypted transmission is standard.

Discreet EU shipping in 48 hours

Neutral packaging, no indication of contents or sender. EU delivery time 24–48 hours, free from 50 € order value. Tracking arrives by email.

Frequent questions on the 100 µg variant