1Fe-LSD

Buy 1Fe-LSD at LSD-Derivate

You want to buy 1Fe-LSD and care about solid data? Reasonable. Every batch is analysed by HPLC, the certificate of analysis you pull online via the batch number. No marketing fluff, just numbers you can verify. Purity consistently above 99 %, EU-wide shipping in 48 hours, free above €50.

Why 1Fe-LSD for research?

Short answer: because 1Fe-LSD is a furoyl-lysergamide and therefore occupies an interesting profile in the acyl family. Instead of an aliphatic butanoyl chain like 1Bp-LSD, a furoyl group sits at the N1 nitrogen — an aromatic five-membered heterocycle containing oxygen. Pharmacologically the compound is inert until esterases in plasma and liver cleave the ester. What remains: classical LSD-25 as the active metabolite.

For research this matters, because the aromatic furoyl group shows different hydrolysis kinetics than purely aliphatic acyl residues. Whoever wants to study the influence of substituent geometry on ester cleavage and onset systematically has a clean comparison variant here.

Why order here?

One thing, done thoroughly: high-purity lysergamides for research. When you want to order 1Fe-LSD, you get HPLC-tested 99 %+ purity, full batch traceability and EU shipping in 48 hours. Every batch is released before sale — if the values don't fit, it doesn't ship.

You get 1Fe-LSD from us in three formats: as blotters, as microdose pellets at 10 µg, and as macrodose pellets at 250 µg, which you'll find via the pellet overview. Drops are not part of the 1Fe-LSD range.

What is 1Fe-LSD?

1Fe-LSD belongs to the group of 1-acylated lysergic acid diethylamides. The name derives from the 1-furoyl substituent: at the indole nitrogen (position 1) sits a furan-2-carboxylic-acid residue. Before enzymatic hydrolysis, 1Fe-LSD is pharmacologically inert; after cleavage you have classical LSD.

Chemical classification

Structurally, 1Fe-LSD is an N1-furoyl derivative of the ergoline system. The furoyl group — that is, the five-membered heterocycle furan with an attached carbonyl function — blocks the N1 position and changes polarity, lipophilicity and stability relative to the free lysergamide. Only ester hydrolysis exposes the free N1 position again, and the active lysergamide with its diethylamide residue develops affinity at the 5-HT2A receptor.

1Fe-LSD as a prodrug of LSD

The prodrug concept is standard in lysergamide research: pharmacologically inert precursor, targeted release of the active compound inside the organism. With 1Fe-LSD, an esterase that cleaves off the furoyl residue handles this job. The active metabolite is chemically identical to the reference compound LSD-25 — the difference is in the release path.

For pharmacokinetic studies this is interesting. Aromatic acyl groups such as furoyl show different hydrolysis kinetics than aliphatic residues (propionyl, butyryl, valeryl). Hydrolysis rate affects onset and half-life — and exactly this variable can be isolated cleanly in a direct comparison against 1Bp-LSD or other acyl derivatives.

Placement in the lysergamide family

Within the 1-acyl lysergamides, 1Fe-LSD takes a special position: it's one of the few furoyl-substituted derivatives. Most siblings carry aliphatic residues — 1P-LSD (propionyl), 1cP-LSD (cyclopropionyl), 1V-LSD (valeryl), 1Bp-LSD (butyryl). The aromatic heterocycle is the geometric and electronic variable that makes 1Fe-LSD attractive for comparison studies on structural influence.

Formats at a glance

1Fe-LSD is available from us in three formats:

• Blotters with defined doses per unit (effect-profile and standard-dose studies).
• Microdose pellets at 10 µg (sub-perceptual dosing, microdosing research).
• Macrodose pellets at 250 µg (higher standard doses, controlled units).

Drops in propylene glycol solution we don't currently carry for 1Fe-LSD. If you need volumetric dosing, the compound 1Bp-LSD is the better choice.

Stability and storage

Lysergamides are sensitive to light, heat and oxygen. With 1Fe-LSD there's an extra wrinkle: the furan ring is more sensitive to strong oxidisers and intense UV light than purely aliphatic acyl groups. So: store dry, dark and cool — ideally in a fridge at 2–8 °C, in the original packaging. That keeps the batch stable for at least 12 months.

Quality control and laboratory analysis

Quality here is not a marketing promise but a number. Every batch of 1Fe-LSD goes through an HPLC analysis. Anything below 99 % purity does not leave our warehouse. The certificate of analysis documents purity, identity and batch number, is viewable online and traceable.

HPLC analysis — how testing works

HPLC is the standard in pharmaceutical analytics. The sample is chromatographically separated, each component quantified by UV detection. With 1Fe-LSD we test not only active compound content but also the impurity profile — meaning potential residues from synthesis or hydrolysis products from improper storage. On selected batches GC-MS is added to confirm molecular identity by mass spectrometry.

Complete batch traceability

Every packaging unit carries a batch number. Reproducible science only works if you know which material you used. Via the batch number you pull the HPLC certificate that is assigned to that exact batch — no detours, no email requests.

Storage & shelf life

When stored properly (dry, dark, 2–8 °C), 1Fe-LSD blotters and pellets remain stable for at least 12 months. Important: keep original packaging sealed, avoid light exposure. Sounds obvious — but it's the difference between a clean sample and furan-ring oxidation.

1Fe-LSD compared to 1Bp-LSD

Research applications of 1Fe-LSD

In practice, 1Fe-LSD ends up in pharmacological, analytical and neuroscientific studies. The aromatic furoyl residue makes the compound interesting for structurally comparative investigations — especially when the question is how different acyl geometries influence hydrolysis kinetics.

Receptor binding at the 5-HT2A receptor

The active metabolite LSD-25 binds in vitro with high affinity at the serotonin 5-HT2A receptor. EC50 values are in the low nanomolar range. What's interesting here is not the binding of the end metabolite itself but the temporal component: how fast does the inert precursor become the active binding partner? That depends on the acyl group.

Pharmacokinetic studies

The prodrug character makes 1Fe-LSD an interesting candidate for PK questions: how does the hydrolysis rate of the furoyl residue differ from butanoyl, propionyl or valeryl residues? Does the aromatic ring influence esterase affinity? With defined formats (blotter, pellet) these questions can be investigated reproducibly.

Microdosing research

For sub-perceptual doses, the 10 µg microdose pellets are the standard solution — a reproducible unit per pellet, no scale, no pipette. Detailed information sits on the microdose page. Current studies investigate the influence of low lysergamide doses on cognitive flexibility, neuroplasticity and mood regulation.

Analytical reference standards

Forensic and toxicology labs need comparison substances for the identification of 1-acylated lysergamides in sample matrices. With an HPLC-tested 1Fe-LSD batch you can prepare calibration solutions for HPLC, GC-MS and LC-MS/MS reproducibly. Requirement: batch-pure substance with certificate — standard with us, not the exception.

Order 1Fe-LSD — easy and discreet

You want to order 1Fe-LSD? No registration marathon, no hidden costs. Pick the product, cart, done. The package ships discreetly, neutral packaging, no hint at the contents.

Fast checkout

Three steps: pick the product, check the cart, complete the order. Orders before 14:00 ship the same business day.

Flexible payment options

We currently accept bank transfer (SEPA), cryptocurrencies and other secure payment methods. Encrypted transmission goes without saying.

Discreet EU shipping in 48 hours

Neutral packaging, no hints at sender or contents. Delivery time within the EU is typically 24–48 hours. From €50 order value we ship free. Tracking arrives by email as soon as the package is on its way.

Frequently asked questions about 1Fe-LSD